G-CQT4R3X2EH Appropriate use of beta lactam - beta lactamase inhibitor combination antibiotics - Microbe Mail

Episode 53

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Published on:

7th May 2024

Appropriate use of β-lactam - β-lactamase inhibitor combination antibiotics

The rampant emergence of antimicrobial resistance, particularly amongst Gram negative organisms, has called for both the discovery of novel agents but also for a review of therapeutics thought to have been long lost in this battle. Enter, the "BLBLIs or BLICs'. In this episode Vin and Ruan speak with the 1st author of the publication "Appropriate use of the new β-lactam - β-lactamase inhibitor combination agents: Ceftazidime-avibactam and Ceftolozane-tazobactam in South Africa", Professor Adrian Brink, and receive a welcomed masterclass on this interesting group of antimicrobials.

About our Guest:

Professor Adrian Brink is Head of the Division: Medical Microbiology, and member of the Institute of Infectious Disease & Molecular Medicine,  Faculty of Health Sciences, University of Cape Town and the National Health Laboratory Services, Groote Schuur hospital, Cape Town, South Africa. 

Prof Brink was founding President of the Federation of Infectious Diseases Societies of Southern Africa and is the founder and currently co-chairs the South African Antibiotic Stewardship Program (SAASP). Prof Brink currently serves on the South African Minister of Health’s Ministerial Advisory Committee (MAC) on Antimicrobial Resistance and representing Africa, is a member of the European Society of Clinical Microbiology and Infectious Diseases International Affairs Subcommittee.

His is main research interests are the clinical and molecular epidemiology of antibiotic-resistant infections, the mechanisms of resistance as a confounder in antibiotic stewardship, the design and implementation of large-scale antibiotic stewardship, diagnostic stewardship and infection prevention and control interventions in low- and middle-income countries. His interests also include the protective, metabolic and immune functions of the gastrointestinal and vaginal biome including the resistome and metabolome. 

Resources from this episode

Best practices: Appropriate use of Beta-lactam/Beta-lactamase inhibitor combinations Ceftazidime-Avibactam and Ceftolozane-Tazobactam)

WHO Priority Pathogens List

Table 1: Data on inhibitor classes, inhibitory mechanisms, and current clinical trial status, Kar D et al., 2023.

Table 6: β-lactam/β-lactamase inhibitor (BL/BLI) combinations in clinical trials or submitted for regulatory approval, Butler et al., 2023

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About the Podcast

Microbe Mail
Microbiology & Infectious Diseases Podcast
Are you looking for a medical podcast covering every day issues in diagnostic tests, antimicrobial therapy and management of infections that is relevant to a low or middle income setting? A show that simplifies complex concepts in an easy to follow conversational format? You've come to the right place. This is Microbe Mail - a medical podcast for the busy practitioner or student covering topics in microbiology, infectious diseases and infection control.
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About your hosts

Vindana Chibabhai

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Vin is an Associate Professor in the Division of Clinical Microbiology and Infectious Diseases (CMID), Faculty of Health Sciences at the University of the Witwatersrand, Johannesburg, South Africa and a practising clinical microbiologist with the National Health Laboratory Service. She is passionate about microbes (of course), antimicrobial resistance, antimicrobial stewardship, diagnostics, healthcare associated infections, fungal infections, One Health...let's just say it's a very long list!

She is always looking for new ways to engage with clinicians and improve their understanding of microbiology and infections. This podcast is the perfect way to do just that!

She loves to be involved in research which will impact management of infections in lower-middle income settings. On Microbe Mail episodes, her views are her own.

Jamie Colloty

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Jamie is a medical officer/sub-investigator currently based at Wits VIDA (Vaccine and Infectious Disease Analytics) Nkanyezi Research site at Rahima Moosa Mother and Child Hospital, Johannesburg. She has completed her Diploma in Tropical Medicine and Hygiene (Wits), Diploma in HIV Management (CMSA), and is undertaking her Masters in Public Health through Imperial College London, with a research focus on culture-confirmed neonatal sepsis and meningitis cases in Johannesburg. She is passionate about antimicrobial stewardship and resistance, as well as the role of climate change on emerging infectious diseases. She is excited to combine her interest in microbiology with the work of the Microbe Mail team!

Nonkululeko Mntla

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"Just call me Nonks".
Despite her proudly South African name being as much of a tongue twister as one of the fascinating organisms she often works with, (Iooking at you Stenotrophomonas maltophilia), she is simply mad about Micro. "How interesting it is to be able to identify what organism is causing an infection, to know how it is causing the infection, what therapy can be used against it, what to do if the organism counterattacks with its arsenal of resistance mechanisms, and how to prevent that organism from spreading. That's what I enjoy most, but there is so much more."

Nonks is a Clinical Microbiologist based in Johannesburg, working in the private field; and is affiliated with the University of the Witwatersrand. She has a passion for bridging the understanding between the pathology noted in the laboratory and the patient at the bedside.

Esther Simone

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Esther is a researcher, writer and podcast editor. She holds a degree in the arts and is currently pursuing a qualification in psychology.
In her own words "The choice to join Microbemail as editor was the easiest one I've ever made. The podcast is fascinating and I learn so much each time I sit down to edit. I see it as a valuable addition to the toolbox of any clinician."

Fathima Suleman

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Dr. Fathima Suleman is a junior doctor, who works in a KZN-based hospital's Microbiology department. She is underway with a Diploma in Tropical Medicine and Hygiene. Her interest lie in antimicrobial stewardship and infectious diseases. She is passionate about bridging the gap between laboratory medicine and clinical medicine. Coming from a background of graphic design, she is eager to add flare to the Microbe Mail social media.

Ruan Marais

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Ruan (Gert) Marais is currently a Medical Microbiology registrar at the University of Cape Town (UCT) with major research interests in the development of novel molecular techniques such a metagenomic sequencing, their translation to clinical care and the development of automated tools to aid clinical decision-making. He graduated as the top student in the final year of medical school at the University of Pretoria. Through a Commonwealth Scholarship he completed a MSc in Molecular Biology and Pathology of Viruses at Imperial College London and received the Dean’s prize for the top student. He further has an MMed in Medical Virology, is a Fellow of the College of Pathologists - Virology and received the UCT Colin Kaplan award for Medical Virology for his contribution to SARS-CoV-2 diagnostic testing.

Vinitha Alex

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Dr. Vinitha Alex is a Clinical Microbiologist based in Johannesburg, South Africa and a Microbiology lecturer affiliated to the University of the Witwatersrand. Her particular areas of interest are antimicrobial stewardship, diagnostic stewardship, infection prevention and control, healthcare informatics, medical training and research and development.
She is keen on taking clinical microbiology to the grass root level, making it understandable & accessible to healthcare providers, particularly in areas of low expertise/ specialist availability. She is passionate about improving guideline compliance, fighting the spread of antimicrobial resistance and creating a system that makes good health economic sense.